AdipoLean II offers a combination of the clinically researched LOWAT^® blend of Ayurvedic herbal extracts combined with Oligonol^®, a lychee and green tea complex containing low molecular weight polyphenols for enhanced efficacy. Research indicates that both LOWAT^® and Oligonol^® help maintain healthy adiponectin expression, offering support for healthy insulin function, glucose uptake and fat utilization. LOWAT^® (LI10903F) is a proprietary blend of Piper betle leaf extract and Dolichos biflorus seed extract combined in a specific ratio. Both herbs have been traditionally used to support healthy glucose metabolism and lipid metabolism. In vitro and animal research determined that this combination and ratio provided maximal efficacy. Research indicates that LOWAT^® targets fat breakdown and helps maintain healthy weight management, at least in part due to boosting adiponectin and moderating ghrelin production. In an 8-week, randomized, double-blind, placebo-controlled trial involving 50 overweight subjects following a standard 2,000 calorie per day diet, supplementation with 300 mg of the LOWAT^® blend, three times daily, promoted healthy lean mass ratio and an average weight loss of 9.4 pounds compared to 3.9 pounds in the placebo group (p=0.00005). Supplementation also resulted in an increase in serum adiponectin levels by 15.35% (p=0.0076) and a decrease in serum ghrelin levels by 20.85% (p=0.0066). Ghrelin is a peptide hormone associated with appetite. The mechanisms of action for Oligonol^® include support for healthy insulin function, adiponectin synthesis and lipolysis. In a double-blind, placebo-controlled study involving 19 individuals, Oligonol^® supported healthy visceral fat composition.^‡